Insulin Resistance: Obesity causes cells to become less insulin-responsive, raising blood sugar and risking type 2 diabetes.
Obese people may have less leptin, which regulates hunger and satiety, leading to overeating and weight gain.
Adipose tissue releases adipokines, which regulate hunger, insulin sensitivity, and inflammation. Obesity causes adipokine dysregulation.
Obese people may have higher Ghrelin levels, which increases appetite and overeating.
Cortisol Production: Chronic stress from obesity can increase cortisol levels, encouraging abdominal fat storage.
Sex Hormones: Obesity can cause hormonal imbalances that affect reproductive health.
Chronic low-grade inflammation, including increased C-reactive protein (CRP), is associated to obesity and metabolic dysfunction.
Obesity disrupts hormonal homeostasis, which can cause metabolic irregularities and metabolic syndrome.